Intranasal Injection Versus Topical Administration of Epinephrin During Endoscopic Sinus Surgery
Status:
Unknown status
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Intranasal injection of epinephrine is used routinely during endoscopic sinus surgery (ESS)
to reduce bleeding in the nasal mucosa and thereby improve visualization of the surgical
field. However, systemic absorption of epinephrine via the nasal mucosa is often accompanied
by cardiovascular side effects during the early postinjection period, putting in risk
patients with cardiovascular morbidity. Evidence indicate that topical administration of
epinephrine achieves similar hemostatic effects compared with injection of epinephrine, while
avoiding systemic adverse effects. We wish to conduct a prospective controlled trial
assessing the hemostatic and hemodynamic effects of intranasal injection compared to topical
application of epinephrin during ESS, in order to evaluate whether the previous could be
avoided due to its untoward effects.
We hypothesize that topical administration of epinephrine provides a hemostatic effect not
inferior to that of intranasal injection while minimizing hemodynamic instability during ESS.