Intralipid for Recurrent Miscarriage

• Status: Completed
• Trial end date: 2016-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

Intralipid infusion can improve the outcome in NK cells positive females with history of recurrent miscarriages undergoing IVF/ICSI cycles.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Woman's Health University Hospital, Egypt
• Treatments: Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria:

• Couples with unexplained secondary infertility

• Three or more prior consecutive clinical miscarriages after either spontaneous pregnancy or after IVF/ICSI.

• Elevated natural killer (NK) cells CD16, CD56 and cells with both CD16/CD56 >12%.

Exclusion Criteria:

• Age above forty years old.

• Antiphospholipid syndrome (lupus anticoagulant and/or anticardiolipin antibodies [IgG or IgM]); other recognised thrombophilic conditions (testing according to usual clinic practice).

• Intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy).

• Abnormal parental karyotype.

• Other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (SLE).

• Disturbances of normal fat metabolism such as pathologic hyperlipemia

• Allergic to it; or to eggs, soybean oil, or safflower oil.

• Severe liver disease, kidney disease, lung disease, anemia, blood clotting disorder.