Intracameral Levofloxacin (0.5%) vs Intracameral Cefuroxime
Status:
Recruiting
Trial end date:
2022-10-01
Target enrollment:
Participant gender:
Summary
Endophthalmitis is a clinical diagnosis made when intraocular inflammation involving both
posterior and anterior chamber; is attributable to bacterial or fungal infection. It is a
serious intraocular inflammatory disorder which can be spread via endogenous or exogenous
access into the eye by infecting organism. Exogenous spread usually happens post intraocular
surgery or procedure (i.e. cataract, vitrectomy, glaucoma filtration surgery) while
endogenous spread is associated with hematogenous spread. The occurrence of endophthalmitis
accounts for serious post-operative complication which can lead to severe vision loss and
even blindness. There are several studies conducted to ascertain the efficiency of
intracameral antibiotic as post-operative endophthalmitis prophylaxis. However, there is
limited study in human using intracameral levofloxacin to evaluate its effect.This study is
designed to compare between intracameral levofloxacin and intracameral cefuroxime in terms of
corneal endothelial cell count and its morphology and central corneal thickness in
uncomplicated phacoemulsification surgery