Intraarticular Corticosteroid Therapy in Perthes Disease.

• Status: Terminated
• Trial end date: 2014-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Legg-Calve-Perthes disease (LCP) represents the loss of blood flow to the head of the femur, resulting in significant hip pain and potential long term disability. This study represents a single center, randomized, prospective, controlled study comparing the treatment of LCP with an intraarticular corticosteroid (triamcinolone hexacetonide) injection with traditional nonoperative treatment.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Seattle Children's Hospital
• Treatments: Triamcinolone; Triamcinolone Acetonide; Triamcinolone diacetate; Triamcinolone hexacetonide

Criteria

Inclusion Criteria:

• age of 4 to 12 years

• diagnosed with Idiopathic osteonecrosis of the femoral head

• symptoms less than 12 months old.

Exclusion Criteria:

• Symptoms for more than 12 months

• Previous treatment other than anti-inflammatories, crutches or bed rest

• Subjects more than 8 years old or have a hand bone age greater than 6 years old and lateral pillar B or B/C disease.

• Bilateral hip disease

• Personal or family history of problems with general anesthesia

• Prior steroid treatment

• Previous diagnosis of:

• Asthma

• Identifiable rheumatologic condition

• Metabolic Diseases (including but not limited to Gaucher's disease or congenital hypothyroidism)

• Sickle cell disease

• Known pain syndrome

• Hip sepsis

• Prior malignancy (solid organ or bone marrow transplant)

• Blood Clotting disorder