Intra-patient Dose Escalation Study of Sorafenib in Advanced Non-small Cell Lung Cancer

• Status: Completed
• Trial end date: 2015-12-23
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine the number of patients with advanced, relapsed non-small cell lung cancer who can tolerate dose escalation sorafenib from 400 mg twice daily to either 600 mg twice daily or 800 mg twice daily. Safety and tolerability of sorafenib will also be examined.

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Wisconsin, Madison
• Collaborator: Bayer
• Treatments: Niacinamide; Sorafenib

Criteria

Inclusion Criteria:

• Histologically or cytologically confirmed, advanced (stage IIIB with pleural effusion, stage IV, or recurrent), kras mutation positive, non-small cell lung cancer (NSCLC)

• Measurable disease per RECIST criteria

• Patients must have received one + prior chemotherapy regimens for NSCLC

• Patients may have treated and clinically stable brain metastases

• Adequate bone marrow, liver and renal function

• Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to the start of treatment

• Women of childbearing potential and men must agree to use adequate contraception (barrier method of birth control) prior to study entry and for the duration of study participation, and for 3 months after last administration of sorafenib

• Patients must have the ability to understand and willingness to sign a written informed consent

• International normalized ratio(INR) < 1.5 or prothrombin time/ partial thromboplastin time (PT/PTT) within normal limits

Exclusion Criteria:

• Prior exposure to a Ras pathway inhibitor

• Any other anti-tumor therapy within 3 weeks of enrollment

• Prior bevacizumab within the past 6 weeks

• An active secondary malignancy except non-melanoma skin cancer

• Cardiac disease: Congestive heart failure > class II NYHA. Patients must not have unstable angina or new onset angina or myocardial infarction within the past 6 months

• Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy

• Uncontrolled hypertension, defined as systolic blood pressure > 150mm Hg or diastolic pressure > 90mm Hg, despite optical medical management

• Known human immunodeficiency virus (HIV) infection or chronic Hepatitis B or C

• Active clinically serious infection > Common Terminology Criteria for Adverse Events (CTCAE) Grade 2

• Thrombolic or embolic events such as cerebrovascular accident including transient ischemic attack within the past 6 months

• Pulmonary hemorrhage/bleeding event >/= CTCAE Grade 2 within 4 weeks of first dose of study drug

• Any other hemorrhage/bleeding event >/= CTCAE Grade 3 within 4 weeks of first dose of study drug

• Serious non-healing wound, ulcer, or bone fracture

• Evidence or history of bleeding diathesis or coagulopathy

• Major surgery, open biopsy or significant traumatic injury within 4 weeks of first study drug

• Use of St. John's Wort or rifampin

• Known or suspected allergy to sorafenib or any agent given in the course of the trial

• Any condition that impairs patient's ability to swallow whole pills

• Any malabsorption problem