Overview

Intra-nasal Naloxone for Treatment of Impaired Awareness of Hypoglycemia

Status:
Terminated
Trial end date:
2021-07-01
Target enrollment:
Participant gender:
Summary
This is a single center, single-blind randomized cross over design trial that will compare the impact of intra-nasal naloxone vs. intra-nasal saline administration during experimental hypoglycemia on day one on responses to experimental hypoglycemia on day two. Investigators intend to enroll 18 individuals to obtain the complete data sets from 15 participants. Expected duration of subject participation is 10-12 weeks. This study will consist of two 2-day intervention visits separated by approximately 8 weeks.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Minnesota
University of Minnesota - Clinical and Translational Science Institute
Treatments:
Hypoglycemic Agents
Insulin
Insulin, Globin Zinc
Naloxone