Intra-discal Injection of Platelet-rich Plasma (PRP) Enriched With Exosomes in Chronic Low Back Pain
Status:
Completed
Trial end date:
2022-07-25
Target enrollment:
Participant gender:
Summary
Intervertebral disc pathology accounts for 40% or more cases of chronic LBP. Available
treatment options do not improve the underlying degenerative condition hence This indicates
the need for new therapies.
intradiscal injection of PRP with exosomes derived from blood may potentially transmit some
of the unique stem cell properties to other stem cells, facilitating stemness maintenance,
differentiation, self-renewal, and repair.
controlled, randomized, double-blind placebo clinical trial to compare the safety and
efficacy of PRP with exosomes in discogenic LBP adminstartion of PRP with exosomes at the
centre of the nucleus pulposus or equal amount of placebo paradiscal patients wil be
elvaluated for primary Outcome measures viz: Visual analog scale (VAS), Roland Morris
Disability Questionnaire (RDQ), SF 36 health questionnaire, Functional rating index and
Secondary: MRI - disc degeneration grading, T2 quantification, and for any Adverse events
including of discitis