Intra-articular Hyaluronic Acid in Mild to Moderate Knee Osteoarthritis

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective:

To assess the impact of intraarticular hyaluronic acid (HA) on clinical outcome and on volumetric and T2 relaxation based changes of articular cartilage in mild to moderate osteoarthritis (OA) of the knee joint.

Methods:

Patients with moderate OA of the knee [Kellgren-Lawrence II] were recruited for a 6-months prospective, randomized clinical trial evaluating the effect of HA on articular cartilage morphology and composition. Clinical examinations and MRI were performed at baseline, and after 6, 12 and 24 weeks. Cartilage volume, thickness and surface area were determined in cartilage plates and subregions were defined using proprietary software. MRI was performed on a 1.5 Tesla scanner; morphological evaluation was performed using 3D T1-w FLASH Waterexcitation (WE) sequences and T2 maps were calculated from a multiecho, spin-echo sequence.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Technische Universität München
• Treatments: Hyaluronic Acid

Criteria

Inclusion Criteria:

• History of mild to moderate OA

• OA grade II

Exclusion Criteria:

• Intraarticular injections in the affected knee

• Oral application of glucosamine and chondroitin sulphate during the last 6 months prior to the beginning of the study

• Clinically significant knee joint effusion

• Neoplasm

• Diabetes mellitus

• Osteonecrosis

• Rheumatoid arthritis or any other inflammatory arthritis diagnosed by American College of Rheumatology criteria.