Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis
Status:
Recruiting
Trial end date:
2022-06-01
Target enrollment:
Participant gender:
Summary
We will recruit a total of 40 patients from the Vanderbilt Sports Medicine Clinics who have
been diagnosed with adhesive capsulitis and have not undergone any previous treatment. The 40
patients will be randomized, with 20 in the control group of 3 intra-articular injections of
40mg Methylprednisolone spaced every two weeks, and 20 in the experimental group of 3
intra-articular injection of 50mg doxycycline spaced every two weeks. Both groups will begin
a standardized physical therapy program within a pain-free range of motion 4 weeks after the
initiation of treatment. We will prospectively follow patients for one year, with follow-up
at 6 weeks, 12 weeks, 6 months, and 12 months after the initiation of treatment.
Outcomes will be measured using the American Shoulder and Elbow Score (ASES) and objective
measurements of shoulder range of motion, which will be collected by the treating physician.
Both the patients and physicians participating in the study will be blinded.