Intra-arterial Versus Systemic Thrombolysis for Acute Ischemic Stroke
Status:
Completed
Trial end date:
2012-07-01
Target enrollment:
Participant gender:
Summary
SYNTHESIS is a pragmatic multicenter randomized controlled trial (RCT), open-label, with
blinded follow-up aiming to determine whether loco-regional intra-arterial (IA) with
recombinant tissue-plasminogen activator (rt-PA) and/or mechanical devices, as compared with
systemic intravenous (I.V.) infusion of rt-PA within 3 hours of ischemic stroke, increases
the proportion of independent survivors at 3 months.