Overview

Intra-arterial Thrombolysis After Successful Thrombectomy for Acute Ischemic Stroke in the Posterior Circulation (IAT-TOP)

Status:
Not yet recruiting

Trial end date:
2026-07-01

Target enrollment:

Participant gender:

Summary

1. The CHOICE study suggested that the use of adjunct intra-arterial alteplase after successful endovascular reperfusion in large vessel occlusion acute ischemic strokes resulted in an increased likelihood of excellent neurological outcome at 90 days. However, CHOICE almost exclusively enrolled anterior circulation occlusions. Therefore, the clinical evidence of the efficacy and safety of post-endovascular reperfusion IAT in posterior circulation stroke is lacking. 2. There is a higher risk of ICH in the anterior circulation stroke than posterior circulation stroke. The investigators think IAT may be safer to be used in posterior circulation stroke. Also, there are more perforator artery in the posterior circulation, so IAT would be more likely to show its benefit. Therefore, the investigators would like to explore IA rt-PA for posterior circulation stroke after successful MT in our RCT.

Phase:

N/A

Details

Lead Sponsor:

Xuanwu Hospital, Beijing

Treatments:

Plasminogen
Tissue Plasminogen Activator