Intestinal Microbiome-based Research for the Prevention of Acute GVHD
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
Hematopoietic stem cell transplantation consists of preconditioning chemotherapy, stem cell
infusion, and engraftment of hematopoietic stem cells. In this process, in the case of
recipients who receive hematopoietic stem cells, their immune system is completely destroyed
and then undergoes a situation in which it is reconstituted. In this process, the diversity
of the intestinal microbiome is reduced, and it is widely known that a severe decrease is
associated with the occurrence of an acute graft-versus-host reaction. Attempts to improve
the intestinal microbiome include prebiotics, probiotics, and postbiotics. Prebiotics can be
expected to improve the intestinal microbiome by acting as nutrients for beneficial bacteria
in the intestine, but their role may be limited in situations where the diversity of the
intestinal microbiome has already decreased. Probiotics are a method to expect improvement of
the intestinal microbiome by administering the beneficial bacteria themselves in the
intestine, but there is a difficulty in reaching the intestine properly through stomach acid,
and there is a risk of causing sepsis in immunocompromised patients. Postbiotics is a product
that beneficial bacteria metabolize and release prebiotics in the intestine, and the
microbiome in the intestine is actually responsible for the function that affects the human
body. Therefore, in this study, postbiotics are administered to patients undergoing
hematopoietic stem cell transplantation who are concerned that the diversity of the
intestinal microbiome may have already decreased, to improve the intestinal microbiome and
hope to prevent graft-versus-host reactions through this. Furthermore, it is intended to
improve the outcome of allogeneic hematopoietic stem cell transplantation.