Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet
Status:
Completed
Trial end date:
2006-05-01
Target enrollment:
Participant gender:
Summary
The kidney plays a crucial role in maintaining salt balance by two opposing physiological
mechanisms: the renal dopaminergic system which enhances salt excretion and the
renin-angiotensin system (RAS) which causes salt retention. Salt-sensitive hypertension
occurs when this balance is altered or abnormal. We hypothesized that this balance is
influenced by salt intake: therefore dietary salt affects the natriuretic response to the
renal dopaminergic agonist Fenoldopam, and the Angiotensin Converting Enzyme inhibitor,
Enalapril.
In this trial we study normal salt balance mechanisms in salt resistant adults with normal
blood pressure.