Interstitial Infusion of IL13-PE38QQR Cytotoxin in Recurrent Malignant Glioma
Status:
Completed
Trial end date:
2007-07-01
Target enrollment:
Participant gender:
Summary
IL13-PE38QQR is an oncology drug product consisting of IL13 (interleukin-13) and PE38QQR (a
bacteria toxin). IL3-PE38QQR is a protein that exhibits cell killing activity against a
variety of IL13 receptor-positive tumor cell lines indicating that it may show a therapeutic
benefit. In reciprocal competition experiments, the interaction between IL13-PE38QQR and the
IL13 receptors was shown to be highly specific for human glioma cells.
IL13-PE38QQR will be infused in two courses of 96 hours each, eight weeks apart, directly
into the malignant brain tumors of patients to determine the dose of drug these patients can
tolerate. After that, the selected dose will be studied to give an estimate of the response
rate, response duration, time to response, and survival after infusing that dose of
IL13-PE38QQR into the recurrent malignant glioma.