Overview

Interpersonal Psychotherapy for Severely Depressed Inpatients

Status:
Terminated

Trial end date:
2004-08-01

Target enrollment:
0

Participant gender:
All

Summary

We examined the hypotheses that severely depressed inpatients treated for 5 weeks with IPT-S plus pharmacotherapy have 1) a higher reduction in depressive symptoms and 2) higher response- and remission rates compared to pharmacotherapy plus CM. For the follow-up period (12 months) we hypothesized a better symptomatic and psychosocial longterm outcome and lower rates of relapse for patients initially treated with combination therapy.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

German Research Foundation

Treatments:

Amitriptyline
Amitriptyline, perphenazine drug combination
Sertraline

Criteria

Inclusion Criteria:

Major Depression (single episode, recurrent or bipolar II) according to the Structured
Clinical Interview for DSM IV (SCID)and a score of ≥ 16 on the 17-item version of the
Hamilton Rating Scale for Depression (HAMD)

Exclusion Criteria:

(1) concurrent diagnosis of bipolar I disorder, primary substance abuse or dependency,
mental disorder due to organic factors, and borderline or antisocial personality disorder,
(2) psychotic symptoms, (3) severe cognitive impairment, (4) contraindications to the study
medication, and (5) being actively suicidal