Internal Radiation Therapy With Y-90 Microspheres, External Radiation Therapy With Tomotherapy, and Fluorouracil in Treating Patients With Newly Diagnosed or Recurrent Pancreatic Cancer and Liver Metastases That Cannot Be Removed By Surgery

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy in different ways and giving it together with chemotherapy may kill more tumor cells.

PURPOSE: This phase II trial is studying the side effects and how well giving internal radiation therapy and external radiation therapy together with fluorouracil works in treating patients with newly diagnosed or recurrent pancreatic cancer and liver metastases that cannot be removed by surgery.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Goshen Health System
• Treatments: Fluorouracil

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed pancreatic cancer with liver metastases

• Unresectable disease AND meets any of the following criteria:

• Newly diagnosed disease

• No prior treatment

• Received prior treatment and progressed

• Underwent prior pancreatectomy and progressed

• Liver-only disease (receives selective internal radiotherapy only)

• No known CNS metastases

• No known diffuse peritoneal metastases

PATIENT CHARACTERISTICS:

• Karnofsky performance status 80-100%

• Life expectancy > 3 months

• WBC ≥ 1,500/mm³

• Platelet count ≥ 100,000/mm³

• Hemoglobin ≥ 9 g/dL

• Bilirubin < 2 mg/dL (without extrahepatic biliary obstruction)

• Albumin > 2 g/dL

• Creatinine < 2 mg/dL

• Not pregnant

PRIOR CONCURRENT THERAPY:

• See Disease Characteristics

• Prior surgery, chemotherapy, and biologic therapy allowed

• No prior external beam radiotherapy to liver or pancreatic bed