Intermittent Treatment With Sulfadoxine-pyrimethamine for Malaria Control in Infants

• Status: Completed
• Trial end date: 2005-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to assess the effectiveness of Intermittent Preventive Treatment in Infants (IPTi) with Sulfadoxine-Pyrimethamine to reduce the numbers of malaria attacks, episodes of anemia, and the overall morbidity and mortality

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bernhard Nocht Institute for Tropical Medicine
• Collaborators: Deutscher Akademischer Austausch Dienst; German Federal Ministry of Education and Research; The Volkswagen Foundation
• Treatments: Fanasil, pyrimethamine drug combination; Pyrimethamine; Sulfadoxine

Criteria

Inclusion Criteria:

• Informed consent by parent/guardian (written or oral)

• Permanent residentship in the study area

• Age of 3 months +/-4 weeks

Exclusion Criteria:

• Hypersensitivity to sulfonamides or pyrimethamine (skin rashes, evidence of hemolysis including dark urine and/or purpura, presumptive signs of bone marrow depression such as sore throat and/or mouth ulcers)

• Other severe adverse events related to pyrimethamine-sulfadoxine application

• Signs of severe hepatic or renal dysfunction not due to malaria

• Other reasons after decision of the study physician