Intermittent Preventive Treatment of Malaria in Schoolchildren
Status:
Completed
Trial end date:
2008-06-01
Target enrollment:
Participant gender:
Summary
This will be a randomized, single-blinded, placebo-controlled trial to evaluate the efficacy,
safety and tolerability of antimalarial regimens in healthy schoolchildren. The primary
objective of the study is to compare the efficacy of different combination antimalarial
regimens, including amodiaquine + sulfadoxine-pyrimethamine (AQ+SP),
dihydroartemisinin-piperaquine (DP), and placebo, to SP for intermittent preventive treatment
(IPT) in schoolchildren, as measured by risk of parasitaemia (unadjusted by genotyping) after
42 days of follow-up. This will assess both the efficacy for treatment of asymptomatic
infections and the efficacy for prevention of new infections.
Phase:
Phase 3
Details
Lead Sponsor:
Gates Malaria Partnership London School of Hygiene and Tropical Medicine
Collaborators:
London School of Hygiene and Tropical Medicine Ministry of Health, Uganda Uganda Malaria Surveillance Project