Interleukin-1 Receptor Antagonist for the Treatment of Heart Failure in Patients With Left Ventricular Assist Devices
Status:
Completed
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Heart failure remains a major cause of morbidity and mortality. Many patients with heart
failure receive support from a left ventricular assist device (LVAD) at some point in the
course of their disease. Some of these LVAD patients experience a durable recovery after
ventricular unloading with an LVAD, which may be associated with inhibition of inflammatory
cytokines. This small pilot study aims to determine the biologic and clinical efficacy of an
interleukin-1 receptor antagonist (Anakinra) at inducing myocardial recovery in patients
supported with left ventricular assist devices.