Interferon-gamma With Interferon Alpha and Ribavirin for Hepatitis C Non-responders
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
When administered simultaneously, interferon-alpha 2b + interferon-gamma result in dramatic
antiviral synergy.Ribavirin has shown to enhance interferon-gamma levels in patients with
chronic hepatitis C treated with interferon-alpha. Enhancement of immune responses,
especially those related to type-1 T helper cell activity, may contribute to better efficacy
in combining ribavirin with IFN-alpha for treatment of chronic hepatitis C. The aim of the
present study is to evaluate the efficacy and safety of a triple regimen, a combination
treatment with Interferon gamma, Interferon alfa-2b plus Ribavirin in patients who have not
previously responded to interferon alpha in combination of ribavirin.