Interferon-Induced Gene Expression in Liver Cells and Peripheral Blood Lymphocytes
Status:
Completed
Trial end date:
2006-06-01
Target enrollment:
Participant gender:
Summary
This proposal seeks to use DNA analyses to understand how racial and genetic factors
influence interferon (treatment) response in HCV infection in African Americans. A better
understanding should allow rational design of new therapies or better use of existing
therapies. Patients will provide medical history and undergo a physical exam, blood draws,
electrocardiogram, possible chest x-ray, and abdominal ultrasound. Patients will be admitted
to the hospital for 5 days and undergo 2 liver biopsies, sedation, and multiple blood draws.
Twenty adult male volunteers (10 Caucasians,10 African Americans) ages 18 - 65 years will
participate.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)