Overview

Interest of Nasal Provocation Tests for Diagnosis of House Mites Allergic Rhinitis

Status:
Not yet recruiting
Trial end date:
2024-10-31
Target enrollment:
0
Participant gender:
All
Summary
The aim of this clinical trial is to compare the positive predictive value of the combination rapid nasal provocation test (RNTP) + skin tests (TC) + specific immunoglobulins E (IgEs) to the combination of TC + IgEs (strategy currently used in clinical practice) concerning the efficacy of treatment with Allergen immunotherapy (ITA) at 1 year, in patients with symptoms suggesting allergic rhinitis to house dust mites.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Centre Hospitalier Régional Metz-Thionville
Collaborators:
Centre Hospitalier de Verdun
CHU de Reims
University Hospital, Strasbourg, France
Criteria
Inclusion Criteria:

- Patient over 18 years old,

- Patient with persistent mild to severe or moderate to severe intermittent rhinitis
according to ARIA criteria, suspicion of allergic rhinitis to dust mites, and a
positive skin test for mites and / or a positive mite specific IgE assay

- Patient having signed a free and informed consent

Exclusion Criteria:

- Pregnant or breastfeeding women

- Patients under guardianship or curatorship

- Patients under legal protection

- Patients not affiliated to a social security scheme

- Contraindications to performing a RNPT

- Active ENT or respiratory infections.

- Allergy in acute phase

- History of anaphylaxis due to the allergen involved.

- Unstabilized asthma and other obstructive pathologies.

- Severe general illnesses in evolution.

- Hypersensitivity to one of the components of the product

- Simultaneous treatment with beta-blockers or angiotensin-converting enzyme (ACE)
inhibitors,

- Presence of an excessive degree of sensitization (e.g. history, excessive skin
reactions),

- Contraindications to immunotherapy:

- Asthma (uncontrolled)

- Active autoimmune diseases

- Malignant tumors

- Pregnancy (initiation of venereal disease)

- AIDS