Interest of Fluorescein in Fluorescence-guided Resection of Gliomas (FLEGME)
Status:
Recruiting
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
Fluorescence guidance is a safe and efficient tool for glioblastomas resection. The most
widely used technique is based on 5-aminolevulinic acid (5ala), which stains glioblastoma
cells through a metabolic abnormality and thus helps in defining tumoral edges through a
modified microscope. A multicentric, randomized study comparing 5ala guided surgery with
conventional procedures showed that this technique doubles the rate of complete removal on
post-operative magnetic resonance imaging (MRI), and increases the 6 months progression-free
survival. More recently, fluorescein appeared as an interesting alternative fluorophore for
glioblastomas, with a highly reduced cost (2.5 euros versus 1000 euros per dose). However its
use remains scarcely studied and its clinical benefit unsure. In that context, the
investigators propose a randomized trial comparing conventional " white light " surgery with
fluorescein-guided resection of glioblastomas, in order to assess the relevance of this
technique in glioblastomas removal.