Interactions of Hepatitis C Viral (HCV) Dynamics and Immune Activation in HIV Coinfected Patients During HCV Treatment

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to investigate T-cell mediated immune responses to HIV-1 and HCV and determine how these responses are affected by HCV treatment and correlates to response. Furthermore, to study Interferon-inducible protein-10 (IP-10) dynamics during HCV treatment, and correlate this to treatment outcome.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Karolinska Institutet
• Collaborators: Hoffmann-La Roche; The Swedish Research Council
• Treatments: Interferon-alpha; Interferons; Peginterferon alfa-2a; Ribavirin

Criteria

Inclusion Criteria:

• HIV-1 Hepatitis C coinfected adult patients

• Hepatitis C treatment naive

• Stable HIV-1 infection with or without cART

• > 300 CD4+ cell count

Exclusion Criteria:

• Decompensated liver disease

• Ongoing depression

• Ongoing drug abuse

• Other contraindications for interferon or ribavirin treatment