Interactions Between Intravenous Cocaine and Acetazolamide or Quinine
Status:
Completed
Trial end date:
2015-10-07
Target enrollment:
Participant gender:
Summary
Background:
- Scientists are studying medications that may be useful in treating cocaine addiction. It is
important in these studies to know whether study participants are always taking their
medications as directed. This study will look at two chemicals to see if they can be used to
determine whether participants are taking their medications as directed. Because
acetazolamide and quinine can be measured in plasma and urine, they are good test subjects
for this study. They will be given alone, and combined with intravenous cocaine.
Objectives:
- To see how they body handles acetazolamide and quinine alone, and when combined with
cocaine.
Eligibility:
- Individuals between 18 and 50 years of age who have smoked or used IV cocaine for at least
one year and at least three times per month during the three months prior to screening. Urine
test positive for cocaine within the prior 6 months
Design:
- Participants will be screened with a physical exam and medical history. Blood and urine
samples will also be collected.
- This study will involve a 12-day inpatient stay at the National Institutes of Health.
- On days 1, 5, and 10, participants will receive a dose of cocaine. Blood, urine, breath,
and saliva samples will be collected up to 18 times a day for up to about 24 hours.
- On days 2, 3, 4, and 5, participants will receive acetazolamide. Regular blood samples
will be collected on Day 4.
- Day 6 is a wash-out day with no drugs or blood tests.
- On days 7, 8, 9, and 10, participants will receive quinine. Regular blood samples will
be collected on Day 9.
- On day 11, blood, urine, breath, and saliva samples will be collected in the early
morning. Participants will be able to leave later in the day.