Interaction of Sevoflurane Propofol and Remifentanil in Anesthesia for Laparoscopic Surgery
Status:
Unknown status
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
Recently a new model for the interaction of sevoflurane propofol and remifentanil was
developed. The potency of any combination of the three drugs is defined as probability that a
subject tolerates laryngoscopy without movement response. The model allows to compare the
potency of intravenous and inhalation anesthetics. If the model is valid also for other
stimuli than laryngoscopy and for other responses (e.g. blood pressure or heart rate increase
upon stimulation). If the model is valid equipotent concentrations of sevoflurane and
propofol the same remifentanil concentration would be sufficient to suppress hemodynamic
response to a given stimulus. This will be investigated it the study.