Interaction of Apelin and Angiotensin in the Human Forearm Circulation
Status:
Completed
Trial end date:
2010-05-01
Target enrollment:
Participant gender:
Summary
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to
it's apparent ability to counteract the renin-angiotensin system, which is frequently
overactive in many cardiovascular disease.
Angiotensin has a powerful ability to cause blood vessels constrict and reduces their
diameter. One of the actions of apelin is to cause blood vessels to relax and the
investigators specifically wish test the hypothesis that apelin will cause blood vessels
constricted by angiotensin II to relax.