Interaction Study of Clopidogrel 300/75 mg Given Alone or With Omeprazole 80 mg 12 Hours Apart in Healthy Subjects
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
Primary objective:
- Assess the effects of clopidogrel (300 mg loading dose followed by 4 days 75 mg/day) on
Adenosine diphosphate (ADP)-induced platelet aggregation when given either alone in the
morning, or in association with omeprazole 80 mg/day in the evening at a 12-hours
interval in healthy male and female subjects
Secondary Objectives:
- Compare the pharmacokinetic profiles of clopidogrel and its active metabolite when
clopidogrel is given either alone alone in the morning, or in association with
omeprazole in the evening at a 12-hours interval