Interaction Study of Clopidogrel 300/75 mg Given Alone or Concomitantly With Omeprazole 80 mg in Healthy Subjects
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
Primary objective:
- Assess the effects of clopidogrel (300 mg loading dose followed by 4 days 75 mg/day) on
Adenosine diphosphate (ADP)-induced platelet aggregation when given concomitantly with
omeprazole 80 mg/day compared to given alone in healthy male and female subjects
Secondary Objective:
- Compare the pharmacokinetic profiles of clopidogrel and its active metabolite when
clopidogrel is given either alone or concomitantly with omeprazole