Interaction Between St John's Wort and Metformin?

• Status: Completed
• Trial end date: 2014-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The goal of the study is to examine the difference of the pharmacokinetics of metformin with and without a 3 weeks pretreatment of St John's Wort. Furthermore secondary objectives include changes in GLP-1, C-peptide, serum-insulin and plasma-glucose during an oral glucose tolerance test, changes in OCT1 mRNA in plasma and changes in leptin and lipid-profile following this possible interaction.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Southern Denmark
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Men aged 18-64 years

• Homozygous for common genetic variants in the genes organic cation transporter 1/2 (OCT1/OCT2)

• Normal values of biomarkers accounting for: Liver and kidney function, and normal blood glucose

Exclusion Criteria:

• Chronic alcohol abuse

• Hypersensitivity to metformin or St John's Wort

• Daily intake of drugs requiring prescription