Hepatitis C (HCV) infected patients are often in need for an antidepressant. The introduction
of Direct Acting Antivirals such as telaprevir has greatly improved treatment outcome of HCV
infected patients.Telaprevir has been studied with one antidepressant, escitalopram: plasma
concentrations of the antidepressant were reduced by 35% and without dose adjustment this may
lead to inadequate treatment of depressive symptoms. There is a need for more data on
telaprevir drug interactions with other antidepressants.
For a number of reasons, paroxetine may be a good candidate for use together with
telaprevir-containing HCV treatment.
The interaction between paroxetine and telaprevir has not been studied before.