Interaction Between Paracetamol and Lamotrigine: A Clinical Interaction Study
Status:
Completed
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
The investigators will study the effect of paracetamol on the steady state metabolism of
lamotrigine in 12 healthy male volunteers.
Subjects will receive lamotrigine, slowly titrated from 25 mg daily to 100 mg daily over 28
days. On day 36, full plasma and urine PK samples will be drawn. On days 37-40 the subject
will be co-administered 1 gr paracetamol 4 times daily. On day 40 the sampling will be
repeated.
Primary outcome parameter is Lamotrigine AUC before and after coadministration of
paracetamol.