Interaction Between Nalbuphine and Morphine in PCA

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

1. Nalbuphine is opioid mu receptor antagonist and kappa receptor agonist

2. This study was designed to investigate the interaction between nalbuphine and morphine

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Taiwan University Hospital
• Treatments: Morphine; Nalbuphine

Criteria

Inclusion Criteria:

1. Age 18-65 y/o

2. Female patients of ASA physical status I to III

3. Scheduled for elective abdominal hysterectomy, myomectomy, or excision of ovarian tumor

Exclusion Criteria:

1. Patients with a definite diagnosis of chronic pain syndrome, psychiatric disorders, or drug abuse (include opioids, NSAIDs, sedatives, antidepressants)

2. Intraoperative fentanyl use > 3 μg/kg

3. Patients with definite diagnosis of esophageal reflux syndrome

4. Use of sedatives, antiemetics, or antipruritics within 24 hours before operation

5. Surgery > 4 hours or laparoscopy surgery