Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

• Status: Completed
• Trial end date: 2006-09-01
• Target enrollment: 0
• Participant gender: All

Summary

NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members of these drug classes differ in their propensity to such an interaction.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital of Split; University of Split
• Collaborator: Dr Ivancica Pavlicevic Family Practice Office
• Treatments: Acetaminophen; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Hydrochlorothiazide; Ibuprofen; Piroxicam

Criteria

Inclusion Criteria:

• Treated hypertensives of either gender aged between 55 and 76 years

• About 50% with concomitant osteoarthritis of the hip or knee

Exclusion Criteria:

• Normotensive persons or untreated hypertensives

• Individuals outside the age limits

• General exclusion criteria (e.g. uncooperative persons, advanced malignancies, participants in other studies)