Inter- and Intra-individual Variations in Metformin Pharmacokinetics - The Importance of Genes and Drug Interactions
Status:
Completed
Trial end date:
2020-06-13
Target enrollment:
Participant gender:
Summary
The investigators aim to investigate the interindividual variation in metformin AUC in a
large cohort of healthy volunteers after a single dose of metformin. Part 1 is driven by the
hypothesis that metformin AUC and renal clearance exhibit significant interindividual
variation. However this has never been documented in a large cohort of healthy volunteers.
The investigators aim to investigate the potential interaction between codeine and metformin
in the intestine. The hypothesis underlying part 3 is that the increased risk of early
discontinuation of metformin during co-administration with codeine is primarily due to local
inhibition of OCT1 via codeine at the intestinal level.