Intensive Insulin for Severe/Moderate Hypertriglyceridemia Pancreatitis.

• Status: Unknown status
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate the therapeutic efficacy of intensive insulin in patients with hypertriglyceridemia induced moderate/severe acute pancreatitis on the course and outcome of disease.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: First Affiliated Hospital of Wenzhou Medical University
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Diagnosis of hypertriglyceridemia induced acute pancreatitis (AP): Typical pain increase in serum lipase or amylase with serum TG> 1,000 mg/dL (11.3mmol/L) or serum was milky with serum TG> 500 mg/dL(5.65 mmol/L)

• Onset of abdominal pain within <=48h before admission

• moderate severe or severe Acute Pancreatitis according to Atlanta criteria

• except for other AP causes, such as cholelithiasis, alcohol, drugs and so on

Exclusion Criteria:

• other etiologies other than hyperlipidemia leading to AP

• at the same time combined with other etiologies of AP

• appear difficult to reverse respiratory failure, severe systemic circulatory failure, coma and other the endangered symptoms, patients expected to die within 24hours

• disseminated intravascular coagulation, or patients with severe active bleeding

• without informed consent, the patient refused to plasma replacement, and other circumstances may bring significant bias.