Intensive Glycemic Control For Diabetic Foot Ulcer Healing
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
With the available molecular and cellular evidence of impaired wound healing due to
hyperglycemia, investigators postulate hypothesis asking whether intensive glycemic control
could improve diabetic foot ulcer healing rates. A study showed improvement in phagocytic
activity of macrophages after 5 days of intensive glycemic improvement in 21 patients of
diabetes. Another retrospective cohort study studied the effect on HbA1c as predictor of
healing rate in DFU. Latter found significant association of HbA1c with wound area healing
rate. However a recent systematic review failed to find any randomized control trial
comparing the effect of intensive versus conventional glycemic control for treating DFU.
Hence, investigators want to explore the hypothesis by conducting a randomized control trial
with the primary aim of wound healing in patients of diabetic foot ulcer in response to
intensive glycemic control in comparison to conventional glycemic management.
Phase:
Phase 4
Details
Lead Sponsor:
Postgraduate Institute of Medical Education and Research
Collaborators:
All India Institute of Medical Sciences, Bhubaneswar All India institute of medical sciences, Raipur Amrita Institute of medical sciences and research Center kochi Hinduja hospitals mumbai Institute of Post-Graduate Medical Education and Research, Kolkata Jawaharlal Institute of Postgraduate Medical Education & Research Jawaharlal nehru institute of medical education and research Puducherry Max super speciality hospitals New Delhi