Intensive Blood PRessure Control in Patients With Acute Type B AortIc Dissection
Status:
Unknown status
Trial end date:
2019-07-01
Target enrollment:
Participant gender:
Summary
Aortic dissection (AD) aneurysm is a common catastrophic aortic disease in clinical setting.
Conservative therapy of heart rate and blood pressure control in the acute phase is the
essential treatment as guidelines recommended. Nevertheless, there is no unanimous optimal
target for blood pressure in patients with AD so far. The American Heart Association and the
Canadian Cardiovascular Society recommend the blood pressure should be controlled to lower
than 140/90mmHg, while for patients with diabetes or chronic renal failure, the blood
pressure target should be no less than 130/80 mmHg. Recently, the Japanese Circulation
Society recommended that the blood pressure should be controlled to no less than 130mmHg.
However, there was few large-scale, randomized, controlled studies reported on the effect of
different blood pressure control levels on the prognosis of patients with AD. Hence, the
intensive control of blood pressure to <120 mmHg, compared to <140 mmHg, may improve the
patients' outcome. Thus, in this study, the effect of intensive blood pressure control
(<120mmHg) with conventional blood pressure control (<140mmHg) on the prognosis of ABAD
patients will be compared, and to identify the therapeutic efficacy of intensive blood
pressure control on the ABAD patients.