Integrated Pulmonary Index and Opioid Based Patient Controlled Analgesia
Status:
Completed
Trial end date:
2018-08-01
Target enrollment:
Participant gender:
Summary
An optimal analgesic therapy is very important for postoperative recovery. In recent years,
several studies showed that the prevalence of the moderate to severe pain after craniotomy
ranged from 69 to 87% of patients. The investigators showed that the use of morphine based
patient controlled analgesia prevented moderate to severe postoperative pain in patients
undergoing supratentorial craniotomy. Morphine related side effects such as sedation, miosis,
respiratory depression, nausea and vomiting produce a general reluctance for their use in
neurosurgery. Therefore, all patients were closely observed to detect opioid related side
effects in the intensive care unit for 24 hours following surgery in our previous study. The
Integrated Pulmonary Index (IPI) is a new tool that calculates respiratory and hemodynamic
parameters noninvasively. In the present study the investigators will use different doses of
morphine based patient-controlled analgesia and the IPI system to determine more effective
and safer morphine dose for postoperative analgesia following supratentorial craniotomy.