Insulinotropic Effect of GLP-1 and GIP After Dexamethasone

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

In this study we examine whether inducing insulin resistance by dexamethasone in healthy volunteers will lead to a decreased insulinotropic effect of the hormones GLP-1 and GIP.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hvidovre University Hospital
• Treatments: BB 1101; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1

Criteria

Inclusion Criteria:

• Caucasians above 20 and below 45 years of age

• Normal glucose tolerance as assessed by the WHO criteria

• First degree relative and at least 1 second degree relative with type 2 diabetes

• Normal haemoglobin

• Informed consent

Exclusion Criteria:

• Liver disease (ALAT/ASAT > 2 times normal value)

• Kidney disease (S-creatinin > 130uM and/or albuminuria)

• Heart disease (NYHA II, III or IV)

• Treatment with medicine that cannot be paused

• Pregnancy of breast feeding