Muscle loss with aging is a significant contributor to disability in older people. Our
general hypothesis is that loss of muscle with aging, known as sarcopenia, may be due to
inability of muscle to grow in response to insulin. Our goal is to determine the mechanisms
underlying this age-related insulin resistance of muscle proteins, which will allow us to
define in the future specific interventions to target this defect and provide the scientific
basis for the prevention and treatment of sarcopenia.