Insulin Stimulated Vasodilation in Patients With Type 2 Diabetes

• Status: Active, not recruiting
• Trial end date: 2021-07-30
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluates the role of endothelin in insulin stimulated vasodilation and glucose uptake. The subjects will complete an hyperinsulinemic euglycemic clamp with and without blockade of the endothelin receptors.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Southern Denmark
• Collaborator: The University of Texas at Arlington
• Treatments: BQ 788; cyclo(Trp-Asp-Pro-Val-Leu)

Criteria

Inclusion Criteria:

• Type 2 diabetes OR healthy control (no type 2 diabetes)

• BMI<32

Exclusion Criteria:

• heart disease

• pregnancy or birth within 3 month

• smoking

• Kidney disease

• beta-blockers

• insulin treatment (for type 2 diabetics)