Insulin Sensitivity and Substrate Metabolism Before and After Treatment in Patients With Growth Hormone Deficiency

• Status: Completed
• Trial end date: 2009-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic-intramyocellular lipids in patients with growth hormone deficiency (GHD).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Aarhus
• Collaborator: Aarhus University Hospital
• Treatments: Hormones; Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Written informed consent

• Must be of legal age and competent

• Age: >18 and <60 years old

• Presently diagnosed with growth hormone deficiency; if panhypopituitary, the patient must be sufficiently substituted in the other axis´s, for at least 3 months before inclusion in the study

Exclusion Criteria:

• Alcohol consumption >21 units per week

• Malignant disease

• Pregnancy

• Magnetic implants or material in the body

• Claustrophobia

• BMI >30

• Heart disease (NYHA >2)

• Uncontrolled hypertension

• Manifest diabetes mellitus

• Change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.

Controls are matched on age, gender and BMI

Inclusion Criteria:

• Written informed consent

• Must be of legal age and competent

Exclusion Criteria:

• Alcohol consumption >21 units per week

• Malignant disease

• Pregnancy

• Magnetic implants or material in the body

• Claustrophobia

• Heart disease (NYHA >2)

• Uncontrolled hypertension

• Manifest diabetes mellitus

• Change in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial