Insulin Resistance and Mild Cognitive Impairment (IRMCI) Study
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Dementia (Alzheimer's Disease) is sometimes called "Type 3 Diabetes" because of the strong
connection between Type 2 diabetes (a function of insulin resistance) with Dementia.
The investigators therefore hypothesize that Reducing Insulin Resistance using Intensive
Lifestyle Intervention (Exercise and Weight loss) + Metformin Treatment in Prediabetic &
diet-control-only Diabetic overweight and mildly cognitively impaired individuals 55 years or
older would lead to better Cognitive Function (compared to standard care) after 2 years.
Subjects will be monitored and assessed using a battery of Cognitive and psychological tests
and PET scans to demonstrate glucose utilization in the relevant areas of the brain.
This 3-year open-label study aims to recruit 360 subjects with 50% (180 subjects) randomized
to receiving Intensive lifestyle intervention with Metformin (if diabetic) vs the other 50%
who would receive only the usual standard level of care in the primary care setting.
Phase:
Phase 4
Details
Lead Sponsor:
SingHealth Polyclinics
Collaborators:
Agency for Science, Technology and Research Changi General Hospital Duke-NUS Graduate Medical School Khoo Teck Puat Hospital National University Hospital, Singapore National University, Singapore Singapore Clinical Research Institute Singapore General Hospital