Insulin Effects on Metabolism and Cardiovascular Function in Type 2 Diabetes
Status:
Unknown status
Trial end date:
2009-06-01
Target enrollment:
Participant gender:
Summary
Compared to human insulins analogue insulins offer the option of optimizing metabolism also
in type 2 diabetes. Especially, fast acting insulin analogues lower postprandial glucose
levels more effectively than human regular insulin. However, it is not known whether therapy
with analogue insulins can also improve the subclinically impaired myocardial function in
type 2 diabetes. This prospective, randomized, open long term study compared the effects of a
basal-bolus insulin therapy with analogue insulins versus human insulins on metabolic control
and systolic and diastolic myocardial function, testing the hypothesis that optimized
postprandial glucose control improves cardiac function and cardiovascular risk.