The purpose of this study is to evaluate the effects of the medication insulin detemir on
weight, brain function and mood, and on blood vessel and other risk factors for heart
disease. The study will compare how diet and insulin detemir affect areas of the brain that
are involved in food intake and the sense of pleasure people get from eating.
Participants will be randomized into one of 2 groups. Group 1 will follow a low calorie diet
only. Group 2 will follow a low calorie diet and take insulin detemir.
The study is 26 weeks in length and include outpatient visits, inpatient visits, phone and
email contact, questionnaires, diary collection, blood draw and procedures involving MRI and
PET scans. There are 4 inpatient visits at the Vanderbilt Clinical Research Center (CRC). The
inpatient visits require a one night 2 day stay on the CRC at Weeks 2, 6, 16, 26. During the
weekly and bi-weekly outpatient visits participants will meet with the study nurse and
dietitian.