Overview

Input of the Use of Indometacin in Gitelman Syndrome as Compared to Potassium Sparing Diuretics

Status:
Completed
Trial end date:
2013-01-01
Target enrollment:
0
Participant gender:
All
Summary
Gitelman syndrome is a rare renal disease where the kidneys are unable to normally retain some salts (sodium, potassium and magnesium). Main consequences of these renal leaks of salts are a tendency toward low blood pressure, hypokalemia and hypomagnesemia both contributing to cardiac and muscles symptoms.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Treatments:
Amiloride
Diuretics
Diuretics, Potassium Sparing
Eplerenone
Indomethacin
Sodium Channel Blockers
Criteria
Inclusion Criteria:

- patients 18-60 yrs old, both sex, with genetically proven Gitelman's syndrome, under
birth pill control for woman.

Exclusion Criteria:

- counter-indication to treatment under study

- Other diuretic or NAIS treatments than amiloride, spironolactone, or indometacin