Innovative MRI Techniques to Improve Treatment Stratification of Patients With Esophageal Cancer
Status:
Completed
Trial end date:
2018-05-01
Target enrollment:
Participant gender:
Summary
The current standard treatment of resectable esophageal cancer consists of neoadjuvant
chemoradiation followed by resection. However, some patients develop recurrent disease
despite chemoradiation and additional (systemic) treatment might have been indicated. Other
patients show a (nearly) complete response after chemoradiation and could possibly have been
treated with a less extensive treatment regimen. In patients without a threatened
circumferential resection margin (CRM) and lymph node metastases chemoradiotherapy could
possibly be omitted.
Better stratification of patients with esophageal cancer is therefore urgently needed.
Functional magnetic resonance imaging techniques (MRI) can provide in vivo, quantitative
information on tumor biology and may prove to be a useful non-invasive tool for this purpose.
In this project, ultra-small superparamagnetic particles of iron oxide (USPIO) enhanced MRI
using ferumoxytol (Rienso®), diffusion weighted MRI (DWI) and T2* MRI will be developed, both
in terms of improvement of acquisition and data processing techniques.
Phase:
N/A
Details
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)