Initial Screening of Gemfibrozil as a Novel Treatment for Tobacco Addiction
Status:
Completed
Trial end date:
2016-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the effect of gemfibrozil on nicotine
reinforcement and cue-elicited craving. Other objectives of this study include screening for
the ability of gemfibrozil to aid smoking abstinence during a brief quit attempt and
examining the validity of using laboratory measures of tobacco dependence to predict smoking
abstinence. It is hypothesized that gemfibrozil will result in diminished nicotine
reinforcement, an attenuated response to smoking cues, and an increase in smoking abstinence
compared with placebo. It is also hypothesized that the laboratory measures will prove valid
in predicting abstinence.