Initial Assessment of the Effect of the Addition of Disulfiram (Antabuse) to Standard Chemotherapy in Lung Cancer
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
Recent studies in laboratory animals demonstrate the ability of disulfiram to significantly
inhibit the growth and metastasis of a mouse model of lung cancer. Work with cells in vitro
support the idea that this inhibition is mainly due to the inhibition of angiogenesis - the
formation of new blood vessels in the tumor. Furthermore, it was found out that the best
effect has been obtained when disulfiram has been used not at the highest dose but at an
optimal dose, which is smaller. Thus, this trial will assess the addition of disulfiram to
chemotherapy in non-small cell lung cancer (NSCLCA).